Triethylamine → 2-[2-[[4-[(dimethylamino)methyl]-2-pyridinyl]methylsulfanyl]ethylamino]-3-methyl-4H-imidazol-5-one

HRID 1285332Notes

Reaction equation

HRID 1285332 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH2:15])[CH:6]=1)[CH3:3].I.[CH3:17][N:18]1[CH2:22][C:21](=[O:23])[N:20]=[C:19]1SC.C(N(CC)CC)C>C(O)C>[CH3:3][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH:15][C:19]2[N:18]([CH3:17])[CH2:22][C:21](=[O:23])[N:20]=2)[CH:6]=1)[CH3:1]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 132773272-(4-Dimethylaminomethyl-2-pyridylmethylthio)ethylamineHCID 202489501-Methyl-2-methylthio-imidazolin-4-one hydroiodide

Product 1

HCID 1784832822-[2-[[4-[(dimethylamino)methyl]-2-pyridinyl]methylsulfanyl]ethylamino]-3-methyl-4H-imidazol-5-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-(Dimethylaminomethyl)pyrid-2-ylmethylthio)ethylamine (2.25 g), 1-methyl-2-methylthio-imidazolin-4-one hydroiodide (2.71 g) and triethylamine (2.18 g) were refluxed in ethanol (50 ml) for 6 hours.

Sources & evidence

ORD record
ord-caf0116fc97b4efb95a8ec2d6e9ce637
Source dataset
uspto-grants-1986_01
Patent number
US04567176

Reaction notes

Loading…