反应详情

Doxepin hydrochloride (10 g., 0.032 mol) was dissolved in 50 ml. H2O. Sodium bicarbonate (3.2 g., 0.038 mol) suspended in 25 ml. of H2O was added with stirring, and the mixture stirred for 20 minutes and then extracted 3×50 ml. ether. The ether extracts were combined, dried (Na2SO4) and evaporated in vacuo to yield doxepin as an oil (8.33 g.).

1. stirringthe mixture stirred for 20 minutes
2. extractionextracted 3×50 ml
3. dry with materialdried (Na2SO4)
4. customevaporated in vacuo