HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-prolylproline benzyl ester → Isopropanol ethyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-prolylproline benzyl ester | HCID 13091041 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | Prolylproline benzyl ester | HCID 11130444 | — |
| Product | Isopropanol ethyl acetate | HCID 22055037 | 342.9% |
Reaction Steps
34.21 g (85 mmol) of BOC-Pro-Pro-OBzl (VII) were dissolved in 342 ml of a saturated solution of hydrogen chloride in acetic acid at room temperature. After 30 minutes BOC-removal was complete and the solvent was removed in vacuo. From iPrOH/AcOEt 21.60 g (75% yield) of compund VIII were obtained: RfD 0.32; E1.2 1.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567162 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-504ee13f7113462ab7aece77b6320a16 |
| Source note | uspto-grants-1986_01 |