HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → BOC-Val-Pro-Pro-OBzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | Prolylproline benzyl ester | HCID 11130444 | — |
| Product | BOC-Val-Pro-Pro-OBzl | HCID 13988140 | 70% |
Reaction Steps
Starting from 13.79 g (63.45 mmol) of BOC-Val-OH and 21.5 g (63.45 mmol) of HCl.H-Pro-Pro-OBzl (VIII) and operating as described in Step 7, 22.28 g (70% yield) of compound IX were obtained as an oil after purification by column chromatography on silica gel (Merck) 0.040-0.063 mm eluting with ethyl acetate: methanol=98:2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567162 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-13859b8035754951bf8886f7d0d143b7 |
| Source note | uspto-grants-1986_01 |