反应详情

2.5 Grams of 6-(1-oxo-2-piperazinylbutyl)-3,4-dihydrocarbostyril was mixed in 80 ml of methanol and 1.6 g of sodium borohydride was added gradually under stirring at a room temperature in 15 minutes and further stirred at a room temperature for 2 hours. To the reaction mixture was added 5 ml of concentrated hydrochloric acid and the reaction mixture was concentrated under a reduced pressure to dryness. The residue thus obtained was dissolved by adding 10 ml of water and the pH of the solution was adjusted to 6-7 by adding 2N-sodium hydroxide aqueous solution at a room temperature and stirred to precipitate crystals. The crystals were collected by filtration washed with water and dried to obtain 1.2 g of 6-(1-hydroxy-2-piperazinylbutyl)-3,4-dihydrocarbostyril in colorless powder.

1. stirringfurther stirred at a room temperature for 2 hours
2. concentrationthe reaction mixture was concentrated under a reduced pressure to dryness
3. customThe residue thus obtained
4. dissolutionwas dissolved
5. stirringstirred
6. customto precipitate crystals
7. filtrationThe crystals were collected by filtration
8. washwashed with water
9. customdried