Water → HCID 13133069, compound

HRID 1285493Notes

Reaction equation

HRID 1285493 reaction equation
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([CH2:9][C:10]#[N:11])=[C:7](C=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][C:17]1[NH:21][N:20]=[C:19](N)[CH:18]=1.O.[CH3:24][N:25](C)C=O>>[NH2:25][C:24]1[N:20]2[N:21]=[C:17]([CH3:16])[CH:18]=[C:19]2[N:11]=[CH:10][C:9]=1[C:8]1[CH:7]=[CH:6][C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:13][CH:12]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 20249156HCID 20249156, compound

Product 1

HCID 13133069HCID 13133069, compound

Procedure

10.5 g of p-tert.-butyl-2-formylbenzyl cyanide and 4.8 g of 3(5)-amino-5(3)-methylpyrazole in 40 ml of dimethylformamide were refluxed for 3 hours. The mixture was cooled, and 150 ml of water were then added dropwise. The crystals were filtered off under suction and then washed with water and dried under reduced pressure at 50° C. 11.3 g of 7-amino-2-methyl-6-(4'-tert.-butylphenyl)-pyrazolo[1,5-a]pyrimidine of melting point 218° C. were obtained (Compound 5).

Workup

  1. temperatureThe mixture was cooled
  2. filtrationThe crystals were filtered off under suction
  3. washwashed with water
  4. customdried under reduced pressure at 50° C

Sources & evidence

ORD record
ord-52b708b8157048e68ce13740dd08dab0
Source dataset
uspto-grants-1986_01
Patent number
US04567263

Reaction notes

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