Bromo(phenyl)acetic acid → HCID 91991162, compound

HRID 1285501Notes

Reaction equation

HRID 1285501 reaction equation
[SH:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:11][CH:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13]([OH:15])=[O:14]>CC(C)=O>[BrH:11].[S:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[S:1][CH:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13]([OH:15])=[O:14]

Participants

4

Reactant 2

HCID 97919Bromo(phenyl)acetic acidHCID 178418395HCID 178418395, compound

Product 1

HCID 91991162HCID 91991162, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 16.7 g (0.10 m) 2-mercaptobenzothiazole and 21.5 g (0.10 m) α-bromo-α-phenylacetic acid in acetone is heated to reflux for 5 hours and the solvent is then removed. The residual oil is triturated in acetone and 31 g of solid collected. The compound melts at 192°-4° C.

Workup

  1. temperatureto reflux for 5 hours
  2. customthe solvent is then removed
  3. customThe residual oil is triturated in acetone
  4. custom31 g of solid collected

Sources & evidence

ORD record
ord-2958e05113c546ea8ba3cc653dc4abec
Source dataset
uspto-grants-1986_01
Patent number
US04567267

Reaction notes

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