反应详情

A methylene chloride solution of 5.13 g (0.03 m) 2-mercapto-4,5,6,7-tetrahydrobenzothiazole, 6.45 g. (0.03 m) α-bromophenylacetic acid and 6.0 g (0.06 m) triethylamine is heated to gentle reflux overnight. The solution is extracted twice with a dilute hydrochloric acid solution, once with water and is then dried over anhydrous MgSO4. The residual solid after solvent removal is recrystallized from acetonitrile. 7.0 g (77% yield) of title compound, melting at 118°-20° C., is obtained

1. temperatureto gentle reflux overnight
2. extractionThe solution is extracted twice with a dilute hydrochloric acid solution, once with water
3. dry with materialis then dried over anhydrous MgSO4
4. customThe residual solid after solvent removal
5. customis recrystallized from acetonitrile