Aminoacetonitrile → HCID 13560802, compound

HRID 1285508Notes

Reaction equation

HRID 1285508 reaction equation
[NH2:1][CH2:2][C:3]#[N:4].[Cl:5][CH:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:7](Cl)=[O:8]>C(Cl)Cl>[Cl:5][CH:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:7]([NH:4][CH2:3][C:2]#[N:1])=[O:8]

Participants

4

Reactant 2

HCID 10901AminoacetonitrileHCID 102902Chloro(phenyl)acetyl chloride

Product 1

HCID 13560802HCID 13560802, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.2 g (0.10 m) aminoacetonitrile and 19.0 g (0.11 m) α-chlorophenylacetyl chloride are heated to reflux in methylene chloride for 4 hours. The reaction mixture is filtered and the solvent is removed. The residual solid is recrystallized from benzene to give 16.7 g (80% yield) of the title compound, which has a melting point of 73°-4° C.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe solvent is removed
  3. customThe residual solid is recrystallized from benzene

Sources & evidence

ORD record
ord-cf0c00d7fda142799e3eb96de83cf7e2
Source dataset
uspto-grants-1986_01
Patent number
US04567267

Reaction notes

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