Methanol → HCID 10631783, compound

HRID 1285527Notes

Reaction equation

HRID 1285527 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH2:12][CH3:13])[N:3]=1.CO.[CH3:16][NH2:17]>O>[CH2:12]([O:11][C:4]1[N:3]=[C:2]([NH:17][CH3:16])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1)[CH3:13]

Participants

5

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 202494082-Chloro-6-ethoxy-3-nitropyridine

Product 1

HCID 10631783HCID 10631783, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a stirred mixture consisting of 202.6 g (1 mole) of 2-chlor-6-ethoxy-3-nitropyridine and 500 ml of methanol, 202 g (2.6 mole) of a 40% monomethylamine solution is added drop by drop while stirring in the course of 90 minutes and at 25°-30° C. sump temperature. Subsequently, the mixture is again stirred for yet another 5 hours, is reacted with 650 ml of water, and then the product is filtered off by suction, is washed again with ample water and dried. Melting point 106°-7° C., Yield: 183.2 g (92.9% of theory).

Workup

  1. additionis added drop by drop
  2. stirringSubsequently, the mixture is again stirred for yet another 5 hours
  3. filtrationthe product is filtered off by suction
  4. washis washed again with ample water
  5. customdried

Sources & evidence

ORD record
ord-7e19216883ae4399b0ee6d2bf0bae1ec
Source dataset
uspto-grants-1986_01
Patent number
US04567272

Reaction notes

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