Hydrochloric Acid → 2-[2-[bis(1-methylethyl)amino]ethyl]hexahydro-2-phenyl-3(2H)-indolizinone hydrochloride hydrate

Participants

Reaction Steps

A solution of 24% hydrogen chloride in isopropyl alcohol was added to 6.7 g (18 mmole) of the title product of Example 3 until the mixture remained acidic (ca. pH 2). Addition of diethyl ether produced an oil which was separated. Trituration of the oil with additional diethyl ether induced crystallization of the title compound as an analytically pure hydrochloride hydrate, m.p. 93°-97°

Provenance & Evidence