Hydrochloric Acid → HCID 20249406, compound

HRID 1285531Notes

Reaction equation

HRID 1285531 reaction equation
[ClH:1].[CH3:2][CH:3]([N:5]([CH:24]([CH3:26])[CH3:25])[CH2:6][CH2:7][C:8]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16](=[O:17])[N:15]2[CH:10]([CH2:11][CH2:12][CH2:13][CH2:14]2)[CH2:9]1)[CH3:4].C(OCC)C>C(O)(C)C>[OH2:17].[ClH:1].[CH3:26][CH:24]([N:5]([CH:3]([CH3:4])[CH3:2])[CH2:6][CH2:7][C:8]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16](=[O:17])[N:15]2[CH:10]([CH2:11][CH2:12][CH2:13][CH2:14]2)[CH2:9]1)[CH3:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13560813HCID 13560813, compound

Product 1

HCID 20249406HCID 20249406, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 24% hydrogen chloride in isopropyl alcohol was added to 6.7 g (18 mmole) of the title product of Example 3 until the mixture remained acidic (ca. pH 2). Addition of diethyl ether produced an oil which was separated. Trituration of the oil with additional diethyl ether induced crystallization of the title compound as an analytically pure hydrochloride hydrate, m.p. 93°-97°

Workup

  1. customproduced an oil which
  2. customwas separated
  3. customcrystallization of the title compound as an analytically pure hydrochloride hydrate, m.p. 93°-97°

Sources & evidence

ORD record
ord-2e8b3754f6a240cc82c31ab58bb9be0d
Source dataset
uspto-grants-1986_01
Patent number
US04567270

Reaction notes

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