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HRID1285533

反应详情

EQUATION

反应方程式

HRID 1285533 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)CC(=O)OCC(C)C
HCID522677

Butanoic acid, 3-oxo-, 2-methylpropyl ester

C8H14O3

结构：COC(=O)/C=C(/C)N
HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：O=Cc1cccc2nonc12
HCID10290873

4-Benzofurazancarboxaldehyde

C7H4N2O2

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1cccc2nonc12
HCID13231102

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

3 g of 2,1,3-benzoxadiazole-4-aldehyde, 3.2 g of acetoacetic acid isobutyl ester, 2.3 g β-aminocrotonic acid methyl ester and 10 ml of ethanol are stirred under reflux for 3 hours. The mixture is subsequently evaporated and the residue is chromatographed on silica gel with chloroform/acetic acid ethyl ester (8:1) to yield the title compound. The product is recrystallised from diisopropyl ether and methylcyclohexane, m.p. 148°-158°.

WORKUP

后处理

  1. temperatureunder reflux for 3 hours
  2. customThe mixture is subsequently evaporated
  3. customthe residue is chromatographed on silica gel with chloroform/acetic acid ethyl ester (8:1)