HCID 70045178, compound → Ranolazine

HRID 1285543Notes

Reaction equation

HRID 1285543 reaction equation
C(O)(=O)C.[CH3:5][O:6][C:7]1[CH:35]=[CH:34][CH:33]=[CH:32][C:8]=1[O:9][CH2:10][CH:11]([OH:31])[CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:28]([CH3:29])=[CH:27][CH:26]=[CH:25][C:24]=2[CH3:30])=[O:21])[CH2:15][CH2:14]1>S(=O)(=O)(O)O>[CH3:5][O:6][C:7]1[CH:35]=[CH:34][CH:33]=[CH:32][C:8]=1[O:9][CH2:10][CH:11]([OH:31])[CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([CH3:30])=[CH:25][CH:26]=[CH:27][C:28]=2[CH3:29])=[O:21])[CH2:15][CH2:14]1

Participants

3

Reactant 1

HCID 70045178HCID 70045178, compound

Product 1

HCID 56959Ranolazine

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine acetate (1.0 g) is dissolved in 50 ml 50% aqueous sulfuric acid, and the solution evaporated to dryness. The product is suspended in ethanol and filtered, air dried and recrystallized from methanol/acetone to yield 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine.2HSO4.

Workup

  1. customthe solution evaporated to dryness
  2. filtrationfiltered
  3. customair dried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-ce7bed6fb8e44959a6805bcaab383297
Source dataset
uspto-grants-1986_01
Patent number
US04567264

Reaction notes

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