反应详情

温度

170 °C

A mixture of 2-chloro-6-trifluoromethylpyridine (20.0 g), cuprous chloride (0.2 g) and ammonia (specific gravity 0.88, 75 ml) was heated at 170° C. in a pressure vessel for 18 hours. After cooling to ambient temperature, the mixture was extracted with dichloromethane (300 ml). The organic extract was dried and evaporated to give 6-trifluoromethylpyridin-2-amine, m.p. 74°-79° C.

1. temperatureAfter cooling to ambient temperature
2. extractionthe mixture was extracted with dichloromethane (300 ml)
3. extractionThe organic extract
4. customwas dried
5. customevaporated