反应详情

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 60 mg; 0.20 mmol) and azepane (0.23 mL; 2.0 mmol) to 250° C. under microwave irradiation according to the procedure described in Example 14 provided after purification by reverse phase HPLC, 5-azepan-1-yl-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (41 mg, 58%) as an off-white powder. ES-HRMS m/e calcd for C21H33N4O (M+H+) 357.2649, found 357.2644.

1. temperatureHeating
2. customunder microwave irradiation
3. customprovided
4. customafter purification by reverse phase HPLC, 5-azepan-1-yl-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (41 mg, 58%) as an off-white powder