Sodium Hydroxide → HCID 178432386, compound

HRID 128610Notes

Reaction equation

HRID 128610 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][C:11]=1[CH3:12])[N:8]=[CH:7][C:6](C(OCC)=O)=[C:5]2[OH:18].[OH-].[Na+]>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][C:11]=1[CH3:12])[N:8]=[CH:7][CH:6]=[C:5]2[OH:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178469685HCID 178469685, compound

Product 1

HCID 178432386HCID 178432386, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of ethyl 6-bromo-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate (6.7 g), sodium hydroxide pellets (1.7 g) and water (50 ml) was heated at 180° C. in a pressure vessel for 18 hours. The mixture was cooled and filtered to give 6-bromo-7-methyl-1,8-naphthyridin-4-ol, m.p. >250° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-e005898a381f45a6ab0a0c6b25021445
Source dataset
uspto-grants-1995_11
Patent number
US05464781

Reaction notes

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