Phosphorus oxychloride → HCID 19374315, compound

HRID 128619Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[N:12][C:13]=1[CH3:14])[N:10]=[C:9]([CH3:15])[CH:8]=[C:7]2O)[CH3:2].P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:7]1[CH:8]=[C:9]([CH3:15])[N:10]=[C:11]2[C:6]=1[CH:5]=[C:4]([O:3][CH2:1][CH3:2])[C:13]([CH3:14])=[N:12]2

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178465838HCID 178465838, compound

Product 1

HCID 19374315HCID 19374315, compound

Conditions

Temperature: 95 °C

Procedure

6-Ethoxy-2,7-dimethyl-1,8-naphthyridin-4-ol (2.77 g) was added to phosphorus oxychloride (25 ml) at ambient temperature. The mixture was then heated at 95° C. for 1 hour. The mixture was worked up as described in example B1 to give 5-chloro-3-ethoxy-2,7-dimethyl-1,8-naphthyridine, m.p. 144°-7° C.

Sources & evidence

ORD record: ord-3ba0fc06d2784405824d226d2f71ce58
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05464781

Reaction notes

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