反应详情

In a similar manner to Example 1, a mixture of 5-chloro-3-ethoxy-2-methyl-1,8-naphthyridine (2.0 g) and 2-methoxyaniline (1.05 g) in IMS (30 ml) was boiled under reflux for 6 hours then cooled and filtered to give 3-ethoxy-5-(2-methoxyanilino)-2-methyl-1,8-naphthyridine hydrochloride, m.p. 250°-252° C. (with decomposition). Active (1/1) at 30 mg/kg.

1. temperatureunder reflux for 6 hours
2. temperaturethen cooled
3. filtrationfiltered