HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyaniline → 3-Ethoxy-5-(2-methoxyanilino)-2-methyl-1,8-naphthyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | 5-Chloro-3-ethoxy-2-methyl-1,8-naphthyridine | HCID 19374266 | — |
| Product | 3-Ethoxy-5-(2-methoxyanilino)-2-methyl-1,8-naphthyridine hydrochloride | HCID 19374357 | — |
Reaction Steps
In a similar manner to Example 1, a mixture of 5-chloro-3-ethoxy-2-methyl-1,8-naphthyridine (2.0 g) and 2-methoxyaniline (1.05 g) in IMS (30 ml) was boiled under reflux for 6 hours then cooled and filtered to give 3-ethoxy-5-(2-methoxyanilino)-2-methyl-1,8-naphthyridine hydrochloride, m.p. 250°-252° C. (with decomposition). Active (1/1) at 30 mg/kg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464781 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-3493ab135bd94e218c9a1ad37113aa48 |
| Source note | uspto-grants-1995_11 |