Hydrochloric Acid → HCID 45261542, compound

HRID 128651Notes

Reaction equation

HRID 128651 reaction equation
[F:1][C:2]([F:33])([CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)[C:3]([NH:5][NH:6][C:7]([N:9]1[CH2:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[O:12][C:11]2[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:10]1=2)=[O:8])=[O:4].Cl>O>[ClH:24].[F:33][C:2]([F:1])([CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)[C:3]([NH:5][NH:6][C:7]([N:9]1[CH2:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[O:12][C:11]2[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:10]1=2)=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 14976003HCID 14976003, compound

Product 1

HCID 45261542HCID 45261542, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carboxylic acid, 2-[2,2-difluoro-3-hydroxy-1-oxo-3-(2-pyridinyl)propyl]hydrazide, monohydrochloride (11A) was prepared by dissolving 8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carboxylic acid, 2-[2,2-difluoro-3-hydroxy-1-oxo-3-(2-pyridinyl)propyl]hydrazide (11), prepared as described above in Example 11, in N HCl and lyophilizing. Analysis calculated for C22H17N4O4F2Cl.HCl. 1.2 H2O (M.W. 532.94): C, 49.58; H, 3.68; N, 10.51; Cl, 13.30. Found: C, 49.27; H, 3.65; N, 10.53; Cl, 13.01.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-0e4b0a9eaa594fa39a2cab5babc30663
Source dataset
uspto-grants-1995_11
Patent number
US05464830

Reaction notes

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