Furfural → Methyl N-[(furan-2-yl)methyl]-beta-alaninate

HRID 128658Notes

Reaction equation

HRID 128658 reaction equation
S1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11].Cl.NCCC(OC)=[O:19].C(=O)C1OC=CC=1>>[O:19]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 3

HCID 7362FurfuralHCID 2734767Methyl 3-aminopropanoate hydrochlorideHCID 23369385HCID 23369385, compound

Product 1

HCID 21824744Methyl N-[(furan-2-yl)methyl]-beta-alaninate

Procedure

Methyl 3-[(2-furanylmethyl)amino]propanoate (22) was prepared in the manner methyl 3-[(2-thienylmethyl)amino]propanoate (15) was prepared, as described above in Example 15, on a 6.5 mmol scale from methyl β-alaninate hydrochloride and furfural to yield 0.28 g (28%) of product.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-36c471d84c9643188e86021f8da0cef5
Source dataset
uspto-grants-1995_11
Patent number
US05464830

Reaction notes

Loading…