Water → HCID 73605695, compound

HRID 128683Notes

Reaction equation

HRID 128683 reaction equation
[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH:12]=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16].O>N1C=CC=CC=1>[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH:12]=[N:15][OH:16])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 155551412-Phenyl-1,3-oxazole-4-carbaldehyde

Product 1

HCID 73605695HCID 73605695, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 2-phenyloxazole-4-carboxaldehyde (2.18 g, 12.5 mmol) in pyridine (25 ml) was added hydroxylamine hydrochloride (0.96 g, 13.8 mmol) under stirring at room temperature. After 1 hour the mixture was poured into water (200 ml) and the resulting solids were collected, washed with water and dried under vacuum. 2.02 g (10.8 mmol) of the titled compound was obtained: mp 145°-147° C.; IR (KBr) 3195, 3075, 3035, 2850, 1646, 1555, 1486, 1445, 1431 cm-1 ; 1H NMR (270 MHz, CDCl3) d 8.87 (brs,1H), 8.51 (s,1H), 8.09-8.05 (m,2H), 7.68 (sy,1H), 7.52-7.47 (m,3H).

Workup

  1. customthe resulting solids were collected
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-e335a2297ca4423d9d84150480f0d82f
Source dataset
uspto-grants-1995_11
Patent number
US05464849

Reaction notes

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