2-Bromo-1-(2,4-dichlorophenyl)propan-1-one → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazole

HRID 128693Notes

Reaction equation

HRID 128693 reaction equation
[CH:1]1([CH:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:5]([CH2:9][CH2:10][CH3:11])[C:6]([NH2:8])=[S:7])[CH2:3][CH2:2]1.Br[CH:19]([CH3:30])[C:20]([C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1[Cl:29])=O>>[Cl:29][C:23]1[CH:24]=[C:25]([Cl:28])[CH:26]=[CH:27][C:22]=1[C:20]1[N:8]=[C:6]([N:5]([CH:4]([CH:1]2[CH2:3][CH2:2]2)[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH2:9][CH2:10][CH3:11])[S:7][C:19]=1[CH3:30]

Participants

3

Reactant 2

HCID 109239912-Bromo-1-(2,4-dichlorophenyl)propan-1-oneHCID 19374866N-[cyclopropyl(4-pyridyl)methyl]-N-propylthiourea2×

Product 1

HCID 193748794-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazole

Procedure

This compound was prepared according to the process described in Example 1, starting with 1.2 g of N-[cyclopropyl(4-pyridyl)methyl]-N-propylthiourea (Compound 74) and 1.52 g of 2-bromo-1-(2,4-dichlorophenyl)-1-propanone Compound 15). The product was purified on a silica column, using a mixture of methylene chloride and methanol (98:2 V/V) as eluent.

Workup

  1. customThis compound was prepared
  2. customThe product was purified on a silica column
  3. additiona mixture of methylene chloride and methanol (98:2 V/V) as eluent

Sources & evidence

ORD record
ord-429d57366f3b4c00aff825d8adda6674
Source dataset
uspto-grants-1995_11
Patent number
US05464847

Reaction notes

Loading…