HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(2,4-dichlorophenyl)propan-1-one → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(2,4-dichlorophenyl)propan-1-one | HCID 10923991 | — |
| Reactant | N-[cyclopropyl(4-pyridyl)methyl]-N-propylthiourea | HCID 19374866 | — |
| Product | 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazole | HCID 19374879 | — |
Reaction Steps
This compound was prepared according to the process described in Example 1, starting with 1.2 g of N-[cyclopropyl(4-pyridyl)methyl]-N-propylthiourea (Compound 74) and 1.52 g of 2-bromo-1-(2,4-dichlorophenyl)-1-propanone Compound 15). The product was purified on a silica column, using a mixture of methylene chloride and methanol (98:2 V/V) as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464847 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-429d57366f3b4c00aff825d8adda6674 |
| Source note | uspto-grants-1995_11 |