Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 128693Generated: October 29, 2026

2-Bromo-1-(2,4-dichlorophenyl)propan-1-one → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazole

https://huagongshe.com/reaction/128693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(2,4-dichlorophenyl)propan-1-oneHCID 10923991—
ReactantN-[cyclopropyl(4-pyridyl)methyl]-N-propylthioureaHCID 19374866—
Product4-(2,4-dichlorophenyl)-5-methyl-2-{N-[cyclopropyl(4-pyridyl)methyl]-N-propylamino}thiazoleHCID 19374879—

Reaction Steps

This compound was prepared according to the process described in Example 1, starting with 1.2 g of N-[cyclopropyl(4-pyridyl)methyl]-N-propylthiourea (Compound 74) and 1.52 g of 2-bromo-1-(2,4-dichlorophenyl)-1-propanone Compound 15). The product was purified on a silica column, using a mixture of methylene chloride and methanol (98:2 V/V) as eluent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05464847
Source datasetuspto-grants-1995_11
ORD IDord-429d57366f3b4c00aff825d8adda6674
Source noteuspto-grants-1995_11