N-(alpha-cyclopropylbenzyl)-N-propylthiourea → 4-(2-chloro-4-iodophenyl)-5-methyl-2-[N-(alpha-cyclopropylbenzyl)-N-propylamino]thiazole

HRID 128698Notes

Reaction equation

HRID 128698 reaction equation
[CH:1]1([CH:4]([N:11]([CH2:15][CH2:16][CH3:17])[C:12]([NH2:14])=[S:13])[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:3][CH2:2]1.Br[CH:19]([CH3:30])[C:20]([C:22]1[CH:27]=[CH:26][C:25]([I:28])=[CH:24][C:23]=1[Cl:29])=O>>[Cl:29][C:23]1[CH:24]=[C:25]([I:28])[CH:26]=[CH:27][C:22]=1[C:20]1[N:14]=[C:12]([N:11]([CH:4]([CH:1]2[CH2:2][CH2:3]2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:15][CH2:16][CH3:17])[S:13][C:19]=1[CH3:30]

Participants

3

Reactant 2

HCID 18967810N-(alpha-cyclopropylbenzyl)-N-propylthiourea2×HCID 189678472-Bromo-1-(2-chloro-4-iodophenyl)-1-propanone2×

Product 1

HCID 193749114-(2-chloro-4-iodophenyl)-5-methyl-2-[N-(alpha-cyclopropylbenzyl)-N-propylamino]thiazole

Procedure

This compound was prepared from N-(α-cyclopropylbenzyl)-N-propylthiourea (Compound 75) and 2-bromo-1-(2-chloro-4-iodophenyl)-1-propanone (Compound 18) according to the process described in Example 1.

Sources & evidence

ORD record
ord-e57271fb0a4b410c80ca9fde671e8b0e
Source dataset
uspto-grants-1995_11
Patent number
US05464847

Reaction notes

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