Hydrochloric Acid → HCID 178458737, compound

HRID 128711Notes

Reaction equation

HRID 128711 reaction equation
[NH:1]1[C:5]([NH:6][C:7]([C:9]2[S:17][C:16]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[C:10]=2[O:25][CH:26]([CH3:28])[CH3:27])=[O:8])=[N:4][N:3]=[N:2]1.[ClH:29]>CO>[ClH:29].[NH:1]1[C:5]([NH:6][C:7]([C:9]2[S:17][C:16]3[CH2:15][CH2:14][NH:13][CH2:12][C:11]=3[C:10]=2[O:25][CH:26]([CH3:28])[CH3:27])=[O:8])=[N:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178458738HCID 178458738, compound

Product 1

HCID 178458737HCID 178458737, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.10 g (0.245 mmol) of 3-isopropoxy-5-tert -butoxycarbonyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-2-carboxylic acid (1H-tetrazol-5-yl) amide (from Example 7) in 15 mL of 5% (w/w) hydrogen chloride in methanol was stirred at 24° C. for 3 days. The reaction solvent was removed by evaporation under reduced pressure to afford an oil. The oil was crystallized from 10 mL of ethyl acetate/diethyl ether (1:1 v/v) to afford 0.089 g of 3-isopropoxy-6,7-dihydro-4H-thieno[3,2-c]pyridine-2-carboxylic acid (1H-tetrazol-5-yl) amide monohydrochloride, mp 237°-238° C.

Workup

  1. customThe reaction solvent was removed by evaporation under reduced pressure
  2. customto afford an oil
  3. customThe oil was crystallized from 10 mL of ethyl acetate/diethyl ether (1:1 v/v)

Sources & evidence

ORD record
ord-731aa091618b44a995ae849e0f24963d
Source dataset
uspto-grants-1995_11
Patent number
US05464855

Reaction notes

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