1-Cyano-2,3-dimethylisothiourea → HCID 178484998, compound

HRID 1287188Notes

Reaction equation

HRID 1287188 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH2:11].[C:12]([NH:14][C:15](=[N:18][CH3:19])SC)#[N:13]>C(#N)C>[C:12]([NH:14][C:15]([NH:18][CH3:19])=[N:11][CH2:10][CH2:9][S:8][CH2:7][C:6]1[N:5]=[CH:4][NH:3][C:2]=1[CH3:1])#[N:13]

Participants

4

Reactant 2

HCID 1111031-Cyano-2,3-dimethylisothioureaHCID 178433288HCID 178433288, compound

Product 1

HCID 178484998HCID 178484998, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole (17.0 g) and N-cyano-N',S-dimethylisothiourea (11.2 g) in acetonitrile (500 ml) was heated under reflux for 24 hours. Following concentration, the residue was chromatographed on a column of silica gel with acetonitrile as eluant and the product obtained was finally recrystallised from acetonitrile-ether to yield N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine, m.p. 141°-142°.

Workup

  1. temperatureunder reflux for 24 hours
  2. concentrationconcentration
  3. customthe residue was chromatographed on a column of silica gel with acetonitrile as eluant
  4. customthe product obtained
  5. customwas finally recrystallised from acetonitrile-ether

Sources & evidence

ORD record
ord-5b86eff46016404690c4eade6818186d
Source dataset
uspto-grants-1976_10
Patent number
US03984293

Reaction notes

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