1-Cyano-2,3-dimethylisothiourea → HCID 178484998, compound

Participants

Reaction Steps

A solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole (17.0 g) and N-cyano-N',S-dimethylisothiourea (11.2 g) in acetonitrile (500 ml) was heated under reflux for 24 hours. Following concentration, the residue was chromatographed on a column of silica gel with acetonitrile as eluant and the product obtained was finally recrystallised from acetonitrile-ether to yield N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine, m.p. 141°-142°.

Provenance & Evidence