HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-Morpholino-5-methoxy-4,6-dichloro-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 2,4,6-Trichloro-5-methoxypyrimidine | HCID 20271136 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-Morpholino-5-methoxy-4,6-dichloro-pyrimidine | HCID 21507533 | — |
Reaction Steps
150 parts by volume of benzene, 34 parts of 5-methoxy-2,4,6-trichloro-pyrimidine and 17.7 parts of N-methyl-morpholine are introduced into a reactor. The mixture is heated under reflux for 3 hours, then filtered and the solution is evaporated. The residue obtained is recrystallised from ethanol. 30 parts of 2-morpholino-5-methoxy-4,6-dichloro-pyrimidine of melting point 116°C are thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03984411 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-df0fcfee06e1445787ee37ba6282fedf |
| Source note | uspto-grants-1976_10 |