4-Methylmorpholine → 2-Morpholino-5-methoxy-4,6-dichloro-pyrimidine

HRID 1287222Notes

Reaction equation

HRID 1287222 reaction equation
[CH3:1][O:2][C:3]1[C:4]([Cl:11])=[N:5][C:6](Cl)=[N:7][C:8]=1[Cl:9].C[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>C1C=CC=CC=1>[O:16]1[CH2:17][CH2:18][N:13]([C:6]2[N:5]=[C:4]([Cl:11])[C:3]([O:2][CH3:1])=[C:8]([Cl:9])[N:7]=2)[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 79724-MethylmorpholineHCID 202711362,4,6-Trichloro-5-methoxypyrimidine

Product 1

HCID 215075332-Morpholino-5-methoxy-4,6-dichloro-pyrimidine

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

150 parts by volume of benzene, 34 parts of 5-methoxy-2,4,6-trichloro-pyrimidine and 17.7 parts of N-methyl-morpholine are introduced into a reactor. The mixture is heated under reflux for 3 hours, then filtered and the solution is evaporated. The residue obtained is recrystallised from ethanol. 30 parts of 2-morpholino-5-methoxy-4,6-dichloro-pyrimidine of melting point 116°C are thus obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. filtrationfiltered
  4. customthe solution is evaporated
  5. customThe residue obtained
  6. customis recrystallised from ethanol

Sources & evidence

ORD record
ord-df0fcfee06e1445787ee37ba6282fedf
Source dataset
uspto-grants-1976_10
Patent number
US03984411

Reaction notes

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