HCID 131710468, compound → HCID 131710467, compound

HRID 1287230Notes

Reaction equation

HRID 1287230 reaction equation
[ClH:1].[C:2]([CH:10]1[C:15](=O)[N:14]([CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[C:13]2[CH:22]=[CH:23][CH:24]=[CH:25][C:12]=2[S:11]1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:26][Mg+].[Br-]>CCOCC>[ClH:1].[CH3:20][N:19]([CH3:21])[CH2:18][CH2:17][N:14]1[C:13]2[CH:22]=[CH:23][CH:24]=[CH:25][C:12]=2[S:11][CH:10]([C:2]([CH3:26])([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[OH:9])[CH2:15]1

Participants

4

Reactant 2

HCID 131710468HCID 131710468, compoundHCID 178418689HCID 178418689, compound

Product 1

HCID 131710467HCID 131710467, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Interaction of the free base of the product of example 1 with 1 equivalent of CH3MgBr in ether at room temperature forms a Grignard complex which is decomposed with ice water and the ethereal solution dried over anhydrous MgSO4, filtered and the filtrate treated with anhydrous HCl to yield the title product.

Workup

  1. customat room temperature
  2. dry with materialthe ethereal solution dried over anhydrous MgSO4
  3. filtrationfiltered
  4. additionthe filtrate treated with anhydrous HCl

Sources & evidence

ORD record
ord-ae71216fb25f4ab8a4c55764e0744bb1
Source dataset
uspto-grants-1976_10
Patent number
US03984405

Reaction notes

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