Diethyl (ethoxymethylene)malonate → HCID 2801032, compound

HRID 1287255Notes

Reaction equation

HRID 1287255 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([NH2:7])[O:4][N:3]=1.[CH2:8]([O:10][C:11](=[O:22])[C:12](=[CH:18]OCC)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:9]>>[CH2:8]([O:10][C:11](=[O:22])[C:12](=[CH:18][NH:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:9]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 845905-Amino-3-methylisoxazole

Product 1

HCID 2801032HCID 2801032, compound

Procedure

112.5 g. of 3-Methyl-5-aminoisoxazole (1.14 mol.) and 248 g. of ethoxymethylenemalonic acid diethyl ester (1.14 mol.) are heated with stirring for 45 minutes at 130°. After this period, ethanol is removed under reduced pressure. The residue solidifies on cooling and is recrystallized from ethanol, m.p. 134°-136°, yield 245 g. (80%).

Workup

  1. waitAfter this period
  2. customethanol is removed under reduced pressure
  3. temperatureon cooling
  4. customis recrystallized from ethanol, m.p. 134°-136°, yield 245 g

Sources & evidence

ORD record
ord-0cf8029a88d54ae498f4e97827fc6a4c
Source dataset
uspto-grants-1976_10
Patent number
US03984422

Reaction notes

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