Butylamine → HCID 54382374, compound

HRID 1287257Notes

Reaction equation

HRID 1287257 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](OCC)=[C:8]2[C:14]([CH3:15])=[N:13][O:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2].[CH2:19]([NH2:23])[CH2:20][CH2:21][CH3:22]>C1C=CC=CC=1>[CH2:1]([O:3][C:4]([C:6]1[C:7]([NH:23][CH2:19][CH2:20][CH2:21][CH3:22])=[C:8]2[C:14]([CH3:15])=[N:13][O:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 54397045HCID 54397045, compound

Product 1

HCID 54382374HCID 54382374, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

25 g. of 4-ethoxy-3-methylisoxazolo[5,4-b]pyridine-5-carboxylic acid ethyl ester (0.113 mol.) are dissolved in 100 ml. of benzene and after adding 8 g. of butylamine (0.23 mol.), the solution is refluxed for 12 hours. The solvent is distilled off and the residual 4-butylamino-3-methylisoxazolo[5,4-b]pyridine-5-carboxylic acid ethyl ester is recrystallized from ligroin, m.p. 60°, yield 23.5 g. (85%).

Workup

  1. distillationThe solvent is distilled off
  2. customthe residual 4-butylamino-3-methylisoxazolo[5,4-b]pyridine-5-carboxylic acid ethyl ester is recrystallized from ligroin, m.p. 60°, yield 23.5 g

Sources & evidence

ORD record
ord-74682dfed8c0419eb5301ead84b0cdf8
Source dataset
uspto-grants-1976_10
Patent number
US03984422

Reaction notes

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