Carbon Dioxide → HCID 54351450, compound

HRID 1287349Notes

Reaction equation

HRID 1287349 reaction equation
[Br:1][CH2:2][CH2:3][CH:4]([CH3:11])[CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].OS(O)(=O)=O.C([O-])(O)=O.[Na+].C(=O)=O.[CH3:25][CH2:26]OCC>O.C(O)C>[CH2:25]([O:9][C:8](=[O:10])[CH2:7][CH2:6][CH2:5][CH:4]([CH3:11])[CH2:3][CH2:2][Br:1])[CH3:26]

Participants

8

Reactant 5

HCID 280Carbon DioxideHCID 1118Sulfuric AcidHCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 20322125HCID 20322125, compound

Product 1

HCID 54351450HCID 54351450, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

14.0 g of 7-Bromo-5-methylheptanoic acid, 26 ml of absolute ethanol and 1 ml of concentrated H2SO4 were heated to the boil for 10 hours with exclusion of humidity. After cooling the reaction mixture was poured, while stirring and strongly cooling, onto a mixture of 50 ml of ether, 20 ml of water and 6 g of NaHCO3. When the development of CO2 was finished, the organic phase was separated and the aqueous phase was extracted twice with ether. The combined organic phases were washed with a saturated NaHCO-hd 3-solution, dried, evaporated and distilled off.

Workup

  1. temperatureAfter cooling the reaction mixture
  2. additionwas poured
  3. customthe organic phase was separated
  4. extractionthe aqueous phase was extracted twice with ether
  5. washThe combined organic phases were washed with a saturated NaHCO-hd 3-solution
  6. customdried
  7. customevaporated
  8. distillationdistilled off

Sources & evidence

ORD record
ord-8a1bfc5c43e446799f664375315598b4
Source dataset
uspto-grants-1976_10
Patent number
US03984459

Reaction notes

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