3-(Trifluoromethyl)phenyl isocyanate → HCID 152746473, compound

HRID 1287386Notes

Reaction equation

HRID 1287386 reaction equation
[Na].Cl.[C:3]([NH2:9])(=[NH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1>CC(C)=O>[F:10][C:11]([F:21])([F:22])[C:12]1[CH:13]=[C:14]([NH:18][C:19]([NH:8][C:3](=[NH:9])[CH2:4][CH2:5][CH2:6][CH3:7])=[O:20])[CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 5360545SodiumHCID 11615174Pentanimidamide Hydrochloride

Product 1

HCID 152746473HCID 152746473, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 1 but using 2.3 g. sodium in 250 ml. dry acetone, 13.6 g. valeramidine hydrochloride, and 18.7 g. 3-(trifluoromethyl)phenyl isocyanate in 100 ml. dry acetone, there was obtained after recrystallization from acetonitrile 17.9 g. of the hydrochloride of 1-[3-(trifluoromethyl)phenyl]-3-(pentanimidoyl)urea; m.p. 167°-169°C.

Workup

  1. customafter recrystallization from acetonitrile 17.9 g

Sources & evidence

ORD record
ord-1195822c41214dcb93024c18d617ffb6
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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