4-Methylphenyl isocyanate → HCID 152747188, compound

HRID 1287390Notes

Reaction equation

HRID 1287390 reaction equation
[Na].Cl.[C:3]([NH2:9])(=[NH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[C:10]1([CH3:19])[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[O:18])=[CH:12][CH:11]=1>CC(C)=O>[C:10]1([CH3:19])[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:8][C:3](=[NH:9])[CH2:4][CH2:5][CH2:6][CH3:7])=[O:18])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 693254-Methylphenyl isocyanateHCID 5360545SodiumHCID 11615174Pentanimidamide Hydrochloride

Product 1

HCID 152747188HCID 152747188, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 23 but using 2.3 g. sodium in 300 ml. dry acetone, 13.6 g. valeramidine hydrochloride and 13.3 g. 4-tolyl isocyanate in 100 ml. dry acetone, there was obtained after recrystallization from acetonitrile 10.6 g. 1-(4-tolyl)-3-(pentanimidoyl)urea hydrochloride; m.p. 159°-160°C.

Workup

  1. customafter recrystallization from acetonitrile 10.6 g

Sources & evidence

ORD record
ord-553615a6064d446d979c91a04fa354b0
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

Loading…