Acetamidine monohydrochloride → HCID 152747187, compound

HRID 1287392Notes

Reaction equation

HRID 1287392 reaction equation
[Na].Cl.[C:3]([NH2:6])(=[NH:5])[CH3:4].[C:7]1([CH3:16])[CH:12]=[CH:11][C:10]([N:13]=[C:14]=[O:15])=[CH:9][CH:8]=1>CC(C)=O>[C:7]1([CH3:16])[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:5][C:3](=[NH:6])[CH3:4])=[O:15])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 67170Acetamidine monohydrochlorideHCID 693254-Methylphenyl isocyanateHCID 5360545Sodium

Product 1

HCID 152747187HCID 152747187, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 23 but using 4.6 g. sodium in 500 ml. dry acetone, 18.8 g. acetamidine hydrochloride and 26.6 g. 4-tolyl isocyanate in 120 ml. of dry acetone, there was obtained after recrystallization from isopropyl alcohol 27.1 g. 1-(4-tolyl)-3-(acetimidoyl) urea hydrochloride; m.p. 210°-212°C.

Workup

  1. customafter recrystallization from isopropyl alcohol 27.1 g

Sources & evidence

ORD record
ord-14b87ca393294c41b472c4348df7ff7c
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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