Cyclohexyl isocyanate → HCID 152748352, compound

HRID 1287397Notes

Reaction equation

HRID 1287397 reaction equation
[Na].Cl.[C:3]([NH2:9])(=[NH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[CH:10]1([N:16]=[C:17]=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>CC(C)=O>[CH:10]1([NH:16][C:17]([NH:8][C:3](=[NH:9])[CH2:4][CH2:5][CH2:6][CH3:7])=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 18502Cyclohexyl isocyanateHCID 5360545SodiumHCID 11615174Pentanimidamide Hydrochloride

Product 1

HCID 152748352HCID 152748352, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 23 but using 8.4 g. sodium in 1100 ml. dry acetone, 50 g. valeramidine hydrochloride, and 46.4 g. cyclohexyl isocyanate in 300 ml. dry acetone there was obtained, after recrystallization from isopropyl alcohol 58.4 g. 1-cyclohexyl-3-(pentanimidoyl)urea hydrochloride; m.p. 146°-148°C.

Workup

  1. customafter recrystallization from isopropyl alcohol 58.4 g

Sources & evidence

ORD record
ord-9cb12c83ca2149afba7b2c0033924fc0
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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