Acetone → HCID 178444013, compound

HRID 1287402Notes

Reaction equation

HRID 1287402 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Br:16][C:17]1[CH:22]=[C:21]([Br:23])[CH:20]=[CH:19][C:18]=1[N:24]=[C:25]=[S:26]>C1C=CC=CC=1.CCCCCC>[Br:16][C:17]1[CH:22]=[C:21]([Br:23])[CH:20]=[CH:19][C:18]=1[NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26]

Participants

6

Reactant 4

HCID 180Acetone2×HCID 27580452,4-Dibromophenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444013HCID 178444013, compound

Reagents, catalysts & solvents 1

HCID 110624Benzene hexaneSolvent

Procedure

Following a procedure similar to that described in Example 42 but using 2.3 g. sodium in 300 ml. dry acetone, 16.5 g. heptanamidine hydrochloride, and 29.3 g. 2,4-dibromophenyl isothiocyanate (m.p. 68°-70°C.; prepared from 2,4 -dibromoaniline) in 100 ml. dry acetone there was obtained 1-(2,4-dibromophenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 86°-88°C. (from benzene-n-hexane); hydrochloride (14 g.), m.p. 164°-165°C. (from acetonitrile).

Sources & evidence

ORD record
ord-f14c53c5e967483ca8246775f11e3954
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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