Diethyl (ethoxymethylene)malonate → HCID 21508899, compound

HRID 1287423Notes

Reaction equation

HRID 1287423 reaction equation
CCO[CH:4]=[C:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]2[O:25][CH2:24][CH:23]([CH3:26])[NH:22][C:21]=2[CH:27]=1>>[Cl:16][C:17]1[C:27]2[C:11](=[O:13])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:22]3[CH:23]([CH3:26])[CH2:24][O:25][C:20]([C:21]=23)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 215089026-Chloro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine

Product 1

HCID 21508899HCID 21508899, compound

Procedure

Using the method of Example 1, diethyl ethoxymethylene malonate is reacted with 6-chloro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine and the product reacted with polyphosphoric acid to provide ethyl 8-chloro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate, m.p. 205°-206° C.

Sources & evidence

ORD record
ord-a0d1120385994c05a050016a4b37b888
Source dataset
uspto-grants-1976_10
Patent number
US03984548

Reaction notes

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