Allyl bromide → HCID 12395567, compound

HRID 1287432Notes

Reaction equation

[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11][CH3:12])[CH:8]=2)[C:3]1=[O:15].[H-].[Na+].[CH2:18](Br)[CH:19]=C.[CH3:22]OCCOC>>[CH2:1]([C:2]1([CH3:22])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11][CH3:12])[CH:8]=2)[C:3]1=[O:15])[CH:18]=[CH2:19]

Participants

Reactant 4

HCID 7841Allyl bromide

HCID 80711,2-Dimethoxyethane

HCID 24758Sodium hydride

HCID 123955612-Methyl-5-methoxy-6,7-dichloro-1-indanone

Product 1

HCID 12395567HCID 12395567, compound

Procedure

2-Allyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone is prepared following substantially the same procedure described in Example 5, step E, using the following substances: 2-methyl-5-methoxy-6,7-dichloro-1-indanone (14.7 g., 0.06 mole), sodium hydride (1.7 g., 0.072 mole), 1,2 -dimethoxyethane (500 ml.) and allyl bromide (8 ml.). The above procedure gives 11.0 g. of 2-allyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone which after recrystallization from methyl cyclohexane melts at 58° C.

Workup

customThe above procedure gives 11.0 g
customof 2-allyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone which after recrystallization from methyl cyclohexane melts at 58° C.

Sources & evidence

ORD record: ord-9ac4676ab2134261bf77848677f797df
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03984465

Reaction notes

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