2,3-Dichloroanisole → HCID 12395646, compound

HRID 1287451Notes

Reaction equation

HRID 1287451 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](Cl)=[O:19].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:18](=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][Br:11])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 161262,3-DichloroanisoleHCID 6451240Aluminum(III) ChlorideHCID 11368152HCID 11368152, compound

Product 1

HCID 12395646HCID 12395646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared following substantially the same procedure described in Example 13, Step A, using the following substances: 2,3-dichloroanisole (89 g., 0.5 mole), 7-bromoheptanoyl chloride (127 g., 0.56 mole), aluminum chloride (74 g., 0.56 mole) and methylene chloride (500 ml.). This procedure affords 107 g. (58%) of 2,3-dichloro-4-(7-bromoheptanoyl)anisole which after recrystallization from the cyclohexane melts at 57°C.

Workup

  1. customThis procedure affords 107 g
  2. custom(58%) of 2,3-dichloro-4-(7-bromoheptanoyl)anisole which after recrystallization from the cyclohexane melts at 57°C.

Sources & evidence

ORD record
ord-f42600f44d95444db5d2312bdc255ead
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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