Hydrochloric Acid → HCID 20358472, compound

HRID 1287471Notes

Reaction equation

HRID 1287471 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH:23]([CH3:25])[CH3:24])[CH2:18][CH2:19][C:20](=[O:22])[CH3:21].[BH4-].[K+].Cl>O>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH2:18][CH2:19][CH:20]([OH:22])[CH3:21])[CH:23]([CH3:25])[CH3:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4192641Potassium borohydrideHCID 20358469HCID 20358469, compound

Product 1

HCID 20358472HCID 20358472, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
5 °C

Procedure

A stirred suspension of [1-oxo-2-isopropyl-2-(3-oxobutyl)-6,7-dichloro-5-indanyloxy]acetic acid (2.0 g., 0.0052 mole) in water (50 ml.) is cooled to 5° C. and treated over a 1/2 hour period with a solution of potassium borohydride (0.6 g., 0.11 mole). The reaction is stirred at 10°-15° C. for 1/2 hour then acidified with dilute aqueous hydrochloric acid affording [1-oxo-2-(3-hydroxybutyl)-2-isopropyl-6,7-dichloro-5-indanyloxy]acetic acid as a white solid which is filtered, rinsed with water and dried.

Sources & evidence

ORD record
ord-1c0c2ee1ad5a48608abe57dac35a212e
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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