Thiophosgene → HCID 56618003, compound

HRID 1287483Notes

Reaction equation

HRID 1287483 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[Ca+2].[C:14](Cl)(Cl)=[S:15].[CH3:18][C:19]1[C:20]([N:25]=[C:26]=[S:27])=[N:21][CH:22]=[CH:23][CH:24]=1.[N-]=C=S>C(#N)C>[CH3:8][C:7]1[C:2]2=[N:1][C:14](=[S:15])[N:25]([C:20]3[C:19]([CH3:18])=[CH:24][CH:23]=[CH:22][N:21]=3)[C:26](=[S:27])[N:3]2[CH:4]=[CH:5][CH:6]=1

Participants

7

Reactant 5

HCID 10040ThiophosgeneHCID 10112Calcium CarbonateHCID 153472-Amino-3-methylpyridineHCID 215089102-Isothiocyanato-3-methylpyridineHCID 178418790HCID 178418790, compound

Product 1

HCID 56618003HCID 56618003, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the procedure of Examples 1A and 2A, 21.6 g. of 2-amino-3-methylpyridine, 42 g. of calcium carbonate and 24.5 g. of thiophosgene are converted into 3-methyl-2-pyridylisothiocyanate with a b.p. of 84° C. at 0.5 mm. of Hg. 10 G. of the freshly distilled isothiocyanate is dissolved in 100 ml. of acetonitrile and the reaction mixture carried out as in Examples 1B and 2B affording 9-methyl-3-(3-methyl-2-pyridyl) pyrido (1,2-a) 1,3,5-triazine-2,4-dithione m.p. 131°-132° C.

Sources & evidence

ORD record
ord-12754b26c7644200b2e3bef31a0d1476
Source dataset
uspto-grants-1976_10
Patent number
US03984549

Reaction notes

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