Acetic Anhydride → HCID 21509168, compound

HRID 1287504Notes

Reaction equation

HRID 1287504 reaction equation
Cl.[NH2:2][C:3]1[N:4]([CH3:19])[C:5]2[C:10]([C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:20](OC(=O)C)(=[O:22])[CH3:21]>N1C=CC=CC=1>[C:20]([NH:2][C:3]1[N:4]([CH3:19])[C:5]2[C:10]([C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 12500217HCID 12500217, compound

Product 1

HCID 21509168HCID 21509168, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To ten grams of 2-amino-3-(p-chlorophenyl)-1-methylindole hydrochloride in 80 ml. of pyridine, 5.4 ml. acetic anhydride are added under stirring at 20°-25° C. After five hours the pyridine is distilled off in vacuo at 40°-45° C and the oily residue solidifies with water. The product is crystallized from methanol. Yield 7.9 g. M.p. 196°-197° C.

Workup

  1. distillationAfter five hours the pyridine is distilled off in vacuo at 40°-45° C
  2. customThe product is crystallized from methanol

Sources & evidence

ORD record
ord-e8339ad0d91846caa8abd51562b92fea
Source dataset
uspto-grants-1976_10
Patent number
US03984563

Reaction notes

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