Hydrochloric Acid → HCID 12318589, compound

HRID 1287598Notes

Reaction equation

HRID 1287598 reaction equation
[CH2:1]([N:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]([C:14]#[N:15])[CH2:6][C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]1=2)[CH3:2].[ClH:20]>CCOCC>[ClH:20].[CH:4]([N:3]([CH:9]([CH3:10])[CH3:8])[CH2:1][CH2:2][C:7]1([C:14]#[N:15])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:3]([CH2:1][CH3:2])[C:4]2[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=2[CH2:6]1)([CH3:19])[CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12318586HCID 12318586, compound

Product 1

HCID 12318589HCID 12318589, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 28 parts of 10-[2-diisopropylamino)ethyl]-5-ethyl-10,11-dihydro-5H-dibenz[b,f]azepine-10-carbonitrile in a minimal amount of anhydrous ether is acidified with a 20% solution of hydrogen chloride in anhydrous ether. The white solid which precipitates is filtered off, dried in vacuo at 60°-70°, and then recrystallized from absolute ethanol to give 10-[2-(diisopropylamino)ethyl]-5-ethyl-10,11-dihydro-5 H-dibenz[b,f]azepine-10-carbonitrile hydrochloride melting at 230°-233°.

Workup

  1. customThe white solid which precipitates
  2. filtrationis filtered off
  3. customdried in vacuo at 60°-70°
  4. customrecrystallized from absolute ethanol

Sources & evidence

ORD record
ord-aeb823e86e7c46bc8a563640a39c28ff
Source dataset
uspto-grants-1976_10
Patent number
US03985730

Reaction notes

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