Gamma-Butyrolactone → HCID 21402974, compound

HRID 1287628Notes

Reaction equation

HRID 1287628 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][NH2:17])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:18]1(=[O:23])[O:22][CH2:21][CH2:20][CH2:19]1>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][NH:17][C:21](=[O:22])[CH2:20][CH2:19][CH2:18][OH:23])[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7302Gamma-ButyrolactoneHCID 2020415H-Dibenzo(a,d)cycloheptene-5-methylamine, 10,11-dihydro-

Product 1

HCID 21402974HCID 21402974, compound

Procedure

10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-methylamine (8.5 g) and γ-butyrolactone (3.7 g) are heated at 150° C. (internal temperature) for 1 hour. After cooling, the solid residue is recrystallized from benzene to give N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methyl]-4-hydroxybutyramide, (III, Alk = CH2CH2CH2 and Y = OH), m.p. 103°-105° C.

Workup

  1. temperatureAfter cooling
  2. customthe solid residue is recrystallized from benzene

Sources & evidence

ORD record
ord-fc932a7b54934f67b29253353a5182db
Source dataset
uspto-grants-1976_10
Patent number
US03985751

Reaction notes

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