HCID 21505598, compound → HCID 21505648, compound

HRID 1287639Notes

Reaction equation

HRID 1287639 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:24])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:24])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[S:19][CH:20]=[C:21]([CH3:23])[N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 21505598HCID 21505598, compound

Product 1

HCID 21505648HCID 21505648, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A 0.35 g. portion of 3,6-dihydro-α-(p-fluorophenyl)- 4-(4-methyl-2-thiazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 12, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced to room temperature and pressure for about 26 hours. The mixture is filtered and the filtrate evaporated yielding a white solid which is recrystallized from acetonitrile giving a white crystalline solid, m.p. 98°-99° C.

Workup

  1. dissolutionis dissolved in 10 ml
  2. customis reduced to room temperature
  3. filtrationThe mixture is filtered
  4. customthe filtrate evaporated
  5. customyielding a white solid which
  6. customis recrystallized from acetonitrile giving a white crystalline solid, m.p. 98°-99° C.

Sources & evidence

ORD record
ord-22e2ae6c938b417885b03fba167361cc
Source dataset
uspto-grants-1976_10
Patent number
US03985754

Reaction notes

Loading…