HCID 21505598, compound → HCID 21505648, compound

Participants

Reaction Steps

A 0.35 g. portion of 3,6-dihydro-α-(p-fluorophenyl)- 4-(4-methyl-2-thiazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 12, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced to room temperature and pressure for about 26 hours. The mixture is filtered and the filtrate evaporated yielding a white solid which is recrystallized from acetonitrile giving a white crystalline solid, m.p. 98°-99° C.

Provenance & Evidence